WellesleyWeston Magazine

SUMMER 2018

Launched in 2005, WellesleyWeston Magazine is a quarterly publication tailored to Wellesley and Weston residents and edited to enrich the experience of living in two of Massachusetts' most desirable communities.

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Over the coming decades, by measuring enough people in enough different ways, "we can understand the problems before they become problems." Take, for example, diabetes, a disease that Ausiello spent decades studying as a renal specialist. "Blood tests tell us something about a point in time, but without continuous measurement it's very hard to know what signals that you're moving from health and progressing to disease." Doctors today can identify people on the verge of Type II diabetes, which generally occurs later in life. With the right tools and know-how, doctors could eventually alert people a decade before they become prediabetic. By that time, however, the term Type II diabetes would be as outdated as is apoplexy, which a century ago was a catch-all diagnosis for strokes and heart attacks. Similarly, the elevated blood sugar that characterizes Type II diabetes could stem from any number of causes, such as obesity, chronic inflammation, or the combination of genetics and an abnormal response to hormones. The challenge, Ausiello said, is like peeling back the layers of an onion: "How do we begin to stratify so that the word 'diabetes' can dis- appear, and we can start looking at those pathways that are part of the progression from wellness to disease?" One of Ausiello's early ventures was a partnership with Apple, spear- headed by fellow CATCH founder Dr. Stanley Shaw, to create an app for measuring and motivating healthy activities. "I call it Digital Clinical Research 101," Ausiello said. "It was the first effort to look at the mass appeal of a clinical research enterprise." With its GlucoSuccess app, Ausiello's team asked participants with Type II diabetes to record data on physical activity, diet, body weight, and blood sugar levels. Through the app, participants learned how their "It seemed that the perfect match for science and my personality was medicine." an interview with dr. dennis a. ausiello W e l l e s l e y W e s t o n M a g a z i n e | s u m m e r 2 0 1 8 70

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