WellesleyWeston Magazine

SUMMER 2018

Launched in 2005, WellesleyWeston Magazine is a quarterly publication tailored to Wellesley and Weston residents and edited to enrich the experience of living in two of Massachusetts' most desirable communities.

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lived, the stresses we've endured, and the microbiome — the millions of microbes that inhabit our bodies and interact with every organ. "I find like-minded people who share this idea — human phenotyp- ing — human measurement in a continuous and pre-disease state," Ausiello said. The challenge is mind-boggling. Not only is the phenotype a lot to measure, it is everchanging. "There's not going to be a single diagnostic tool, a point on a curve, a certain test," Ausiello said. "It's going to be holistic assessment tools that understand fundamentally the body when it is working well and when it is not working well." Continuous in the CATCH environment does not necessarily mean all the time. "If you're looking at someone's heartbeat, that's about as continuous as it gets, second by second," Ausiello said. "If I'm measuring changes in cellular function at the immune level, that might be once a week or once a month." Compare that with how measurements are typically made. "You go to the doctor and he takes a snapshot — it's very static," Ausiello said. With his many academic connections and his board positions on such companies as pharmaceutical giant Pfizer and Verily Life Sciences (a Google-spinoff that applies high-tech data collection to health ini- tiatives), Ausiello brings together experts who normally wouldn't cross paths. "CATCH's goal is to bring together disparate worlds," he said. "Medicine has been very silo-ized for the 40 or 50 years I've been a par- ticipant. When I was a young researcher, if I wanted to work on the kid- ney, I had to be in the kidney unit. If you wanted to work on the heart, you were in the heart unit." "When you cross-fertilize biology, chemistry, physics, mathematics, and the digital world — and embrace the business world — you've got a cosmopolitan consortium," he continued, with the potential brain- power and tools to understand everything that makes us tick. That means parsing the human condition or phenotype: the interac- tion of body, behavior, and environment. Each of us is the unique prod- uct of our genetic code, the people who influenced us, the places we've "We can understand the problems before they become problems." 68 W e l l e s l e y W e s t o n M a g a z i n e | s u m m e r 2 0 1 8 an interview with dr. dennis a. ausiello

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