WellesleyWeston Magazine

SUMMER 2012

Launched in 2005, WellesleyWeston Magazine is a quarterly publication tailored to Wellesley and Weston residents and edited to enrich the experience of living in two of Massachusetts' most desirable communities.

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firms or pharmaceutical companies to hasten development and approval. Grant proposals primarily come from the Consortium members' own or complemen- tary projects. To reduce lag time between application and implementation, proposals are much briefer than traditional formats and decisions by CAF's independent Scientific Advisory Board are often reached within two weeks. Most projects are funded for one year, typically with a grant of $100,000, although that varies. CAF is also guided by a Strategic Advisory Board made up primarily of ven- ture capitalists. Since its inception, CAF has funded 36 researchers in 25 labs, including several at MGH and one at the Max Planck Institute in Germany. In 1983, as a young lab technician, Rudy Tanzi worked with Dr. James Gusella's team at MGH on the first use of genetic methods to localize a gene linked to a particular dis- ease, which was Huntington's disease. That pioneering discovery is credited as a lead- up to the groundbreaking Human Genome Project which mapped roughly 25,000 genes. Since 1984, Tanzi has focused on Alzheimer's. His laboratory at MGH co-discovered the three known genes that can carry mutations causing early-onset familial Alzheimer's (younger than age 60). A fourth known gene, identified at Duke University in 1993, is among those responsible for its late- onset form. 127 summer 2012 | WellesleyWeston Magazine

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