WellesleyWeston Magazine

SPRING 2013

Launched in 2005, WellesleyWeston Magazine is a quarterly publication tailored to Wellesley and Weston residents and edited to enrich the experience of living in two of Massachusetts' most desirable communities.

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PETER BAKER Pioneering Doctors KELLEY TUTHILL and daughters X prostate, ovarian, and colorectal cancers. In fact, Vasconcelles describes functions, including circulating blood and how different chemicals his industry as, "the ultimate in delayed gratification." added to the fish's water diffuse into the embryo. Over the past five For several years Dr. Vasconcelles has worked closely with fellow years, his lab has identified over 30 mutant genes that affect the process Wellesley resident Dr. Leonard Zon, a hematologist/oncologist pioneer by which stem cells become blood cells, some of which represent excel- in the fields of cancer genetics and stem cell biology. Zon is currently lent animal models of disease. One of Zon's zebrafish gene studies the Grousbeck Professor of Pediatric Medicine at Harvard Medical offers clues to treating melanoma in humans, the most deadly skin School, Investigator at Howard Hughes Medical Institute, Director of cancer. In addition to his work in the academic research world, Zon is the Stem Cell Program at Boston Children's Hospital, and Chairman of also a co-founder of Fate Therapeutics, a company applying stem cell the Executive Committee at the Harvard Stem Cell Institute. His biology to develop pharmaceuticals that adapt the fate of cells. of hormones on blood cells with sparking his zeal for hematology. cancer, and two, developing chemical or genetic suppressors to cure Zon's wife, Dr. Lynda Schneider, the Director of the Allergy Program at cancer and many other devastating blood diseases. Zon's lab at Boston Boston Children's Hospital, also decided on her area of specialty in Children's Hospital uses zebrafish to study hematopoiesis (the process medical school. Schneider, however, determined her direction in the of forming blood) and cancer. Zebrafish have many characteristics that emergency room, not in the classroom, when Zon, her boyfriend at the make them extremely useful in disease research. As vertebrates with a time, gave her a gift of Valentine's Day chocolates that caused her to backbone, they have similar gene sets to humans. In addition, the fish have a severe allergic reaction, necessitating a shot of epinephrine and are transparent, enabling Zon's team to observe all sorts of biological 72 Zon credits a lecture he attended in medical school about the impact stem cells to develop into more specialized blood or organ cells or into We l l e s l e y We s t o n M a g a z i n e | s p r i n g 2 0 1 3 research focuses on two areas: One, identifying the genes that direct fueling her drive to help other people wrestling with allergies.

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